drugtransporterforum.org

Drug Transporter Forum

Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014 OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. Takeuchi et al 2006, Suzuyama et al 2007. Primary hepatocytes h.
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Szabolcs Gczi

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szabszi@solvo.com

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Drug Transporter Forum

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Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014 OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. Takeuchi et al 2006, Suzuyama et al 2007. Primary hepatocytes h.

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The site drugtransporterforum.org had the following on the site, "Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions." I noticed that the website said " Written by Marton Jani, SOLVO Biotechnology." They also stated " The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014 OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. Takeuchi et al 2006, Suzuyama et al 2007."

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